Everything about George Palade totally explained
George Emil Palade (b.
November 19,
1912, in
Iaşi,
Romania) is a Romanian
cell biologist. In
1974, he shared the
Nobel Prize in Physiology or Medicine with
Albert Claude and
Christian de Duve, for his discoveries concerning the structure and function of
organelles in
biological cells.
Biography
George Palade received a
M.D. in
1940 from the
Carol Davila School of Medicine of the
University of Bucharest,
Romania. He was a member of the faculty of that school until
1945 when he went to the United States for postdoctoral studies. There, he joined Prof.
Albert Claude at the
Rockefeller Institute for Medical Research.
In
1952, Palade became a
naturalized citizen of the United States. He was a professor at the Rockefeller Institute (1958-1973),
Yale University Medical School (1973-1990), and
University of California, San Diego (1990-present).
In 1970, he was awarded the
Louisa Gross Horwitz Prize from
Columbia University together with
Renato Dulbecco co-winner of 1974 Nobel Prize in Physiology or Medicine.
Alongside the
Nobel Prize, he received the
National Medal of Science in
1986.
At the Rockefeller Institute, Palade used
electron microscopy to study the internal organization of such cell structures as
mitochondria,
chloroplasts, the Golgi apparatus, and others. His most important discovery was related made while using an experimental strategy known as a
pulse-chase experiment. In the experiment Palade and his colleagues were able to confirm an existing hypothesis that a secretory pathway exists and that the
Rough ER and the
Golgi apparatus function together.
His name has become
attached to the
Weibel-Palade bodies (a storage organelle unique to the
endothelium, containing
von Willebrand factor and various proteins) which he described together with the
Swiss anatomist
Ewald R. Weibel (Weibel ER, Palade GE. New cytoplasmic components in arterial endothelia. J Cell Biol 1964;23:101-112).
Palade is married to
Marilyn Farquhar, a cell biologist at the
University of California, San Diego.
Further Information
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